JI Team Publications

Since the partnership's launch, Joint Institute research teams have produced 150 publications. Their work has touched on a variety of disciplines and appeared in leading journals in their respective fields, including Nature Genetics, Molecular Psychiatry, Cell and Science.

2023

Development and Validation of MyProstateScore 2.0 to Detect Clinically Significant Prostate Cancer
MedRxiv
UM PI: Arul Chinnaiyan

 

Spatiotemporal Local and Abscopal Cell Death and Immune Responses to Histotripsy Focused Ultrasound Tumor Ablation
Frontiers in Immunology
UM PI: Clifford Cho

 

Current Landscape of Genomic Biomarkers in Clear Cell Renal Cell Carcinoma
European Oncology
UM PI: Ganesh Palapattu

 

Galectin-3-centered Paracrine Network Mediates Cardiac Inflammation and Fibrosis Upon β-adrenergic Insult
Science China. Life Sciences
UM PI: Marschall Runge
PKUHSC PI: Youyi Zhang

 

Role of Peptidylarginine Deiminase and Neutrophil Extracellular Traps in Injuries: Future Novel Diagnostics and Therapeutic Targets
Shock
UM PI: Yongqing Li

 

Metformin Directly Binds to MMP-9 to Improve Plaque Stability
Journal of Cardiovascular Science and Disease
PKUHSC PI: Youyi Zhang

 

The Role of the Inflammasome in Heart Failure
Frontiers in Physiology
PKUHSC PI: Youyi Zhang

 

2022

Editorial: Targeting Protein Post-Translational Modifications (PTMs) for Diagnosis and Treatment of Sepsis
Frontiers in Immunology
UM PI: Yongqing Li
PKUHSC PI: Panpan Chang

 

Soluble LILRA3 is Aberrantly Expressed in Antiphospholipid Syndrome (APS) and is a Potential Marker of Thrombotic APS
Rheumatology
UM PI: Jason Knight
PKUHSC PI: Jianping Guo

 

Impact of Histotripsy on Development of Intrahepatic Metastases in a Rodent Liver Tumor Model
Cancers
UM PI: Clifford Cho

 

Prediction of Pathogenic Factors in Dysbiotic Gut Microbiomes of Colorectal Cancer Patients Using Reverse Microbiomics
Frontiers in Oncology
UM PI: Oliver He

 

Systemic Investigation of the Microbiome-host Interactions in H. pylori-associated Gastric Cancer Patients
Molecular & Cellular Proteomics
PKUHSC PI: Jianmin Wu

 

Multi-Scalar Data Integration Links Glomerular Angiopoietin-Tie Signaling Pathway Activation With Progression of Diabetic Kidney Disease
Diabetes
UM PI: Wenjun Ju
PKUHSC PI: Min Chen

 

Molecular Characterization of Clear Cell Renal Cell Carcinoma Reveals Prognostic Significance of Epithelial-mesenchymal Transition Gene Expression Signature
European Urology Oncology
UM PI: Ganesh Palapattu

 

Clinical Outcomes in a Cohort of Patients with Cutaneous T-cell Lymphoma and COVID-19
JAAD International
UM PI: Trilokraj Tejasvi

 

PEG10 Amplification at 7q21.3 Potentiates Large-cell Transformation in Cutaneous T-cell Lymphoma
Blood
UM PIs: Trilokraj Tejasvi and Alex Tsoi
PKUHSC PI: Yang Wang

 

2021

Improved diagnostic prediction of the pathogenicity bloodstream isolates of Staphylococcus epidermidis
PLoS One
U-M PI: J. Scott Van Epps

 

An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population
Human Molecular Genetics
UM PI: Santhi Ganesh
PKUHSC PI: Yan Zhang

 

Hemoglobin and erythrocyte count are independently and positively associated with arterial stiffness in a community-based study
Journal of Human Hypertension
UM PI: Santhi Ganesh
PKUHSC PI: Yan Zhang

 

Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease
Hypertension
UM PI: Santhi Ganesh
PKUHSC PI: Yan Zhang

 

Exome-wide association study of plasma lipids in >300,000 individuals
Nature Genetics
UM PI: Cristen Willer
PKUHSC PI: Ming Zu

 

Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy
Kidney International
U-M PI: Wenjun Ju & Matthias Kretzler
PKUHSC PI: Min Chen

 

The Prevalence of Diabetic Microvascular Complications in China and the United States
Current Diabetes Reports
U-M PI: Rodica Busui
PKUHSC PI: Luxia Zhang

 

Associations of Genetic Variants Contributing to Gut Microbiota Composition in Immunoglobin A Nephropathy
mSystems
PKUHSC PI: Hong Zhang

 

Potential Roles of Oral Microbiota in the Pathogenesis of Immunoglobin A Nephropathy
Frontiers in Cellular and Infection Microbiology
PKUHSC PI: Hong Zhang

 

Five Novel Loci Are Implicated in Predisposing to IgA Nephropathy by an Exome-Wide Association Study of Han Chinese
Clinical Journal of the American Society of Nephrology
U-M PI: Christine Berthier
PKUHSC PI: Hong Zhang

 

Reverse Microbiomics: a new reverse dysbiosis analysis strategy and its usage in prediction of autoantigens and virulent factors in dysbiotic gut microbiomes from rheumatoid arthritis patients
Frontiers in Microbiology
U-M PI: Oliver He

 

PINA 3.0: mining cancer interactome
Nucleic Acids Research
PKUHSC PI: Jianmin Wu

 

Disclosure of clinically actionable genetic variants to thoracic aortic dissection biobank participants
BMC Medical Genomics
U-M PI: Cristen Willer

 

Ethical Perspectives of Chinese and United States Physicians within a Research Collaborative
Accountability in Research
U-M PIs: Michael Geisser, Joseph Kolars, & Raymond Hutchinson
PKUHSC PI: Yali Cong

 

Advancing science and education through a novel collaboration platform between the University of Michigan and Peking University Health Science Center
FASEB BioAdvances
U-M PI: Joseph Kolars
PKUHSC PI: Qimin Zhan

 

Rapid single-molecule digital detection of protein biomarkers for continuous monitoring of systemic immune disorders
Blood
U-M PI: Yongqing Li

 

Ontological modeling and analysis of experimentally or clinically verified drugs against coronavirus infection
Scientific Data
U-M PI: Oliver He

 

2020

Albuminuria and retinal vessel density in diabetes without diabetic retinopathy: the Kailuan Eye Study. Acta Ophthalmol. 2020.
Acta Ophthalmolgica
PKUHSC PI: Luxia Zhang

 

Immunoproteasome in IgA Nephropathy: State-of-Art and Future Perspectives
International Journal of Biological Sciences
PKUHSC PI: Hong Zhang

 

Perspectives on how mucosal immune responses, infections, and gut microbiome shape IgA nephropathy, and future therapies
Theranostics
PKUHSC PI: Hong Zhang

 

CVCDAP: an integrated platform for molecular and clinical analysis of cancer virtual cohorts
Nucleic Acids Research
PKUHSC PI: Jianmin Wu

 

Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy
Journal for Immunotherapy of Cancer
U-M PI: Clifford Cho

 

Aortic progression and reintervention in patients with pathogenic variants after a thoracic aortic dissection
Journal of Thoracic and Cardiovascular Surgery
U-M PI: Cristen Willer

 

Soluble urokinase-type plasminogen activator receptor and incident end-stage renal disease in Chinese patients with chronic kidney disease
Nephrology Dialysis Transplantation
PKUHSC PI: Minghui Zhao

 

Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis
JCI Insight
U-M PIs: Yongqing Li & Hasan Alam

 

Associations of Urinary Epidermal Growth Factor and Monocyte Chemotactic Protein-1 with Kidney Involvement in Patients with Diabetic Kidney Disease
Nephrology Dialysis Transplantation
PKUHSC PIs: Min Chen, Minghui Zhao & Luxia Zhang

 

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation
Science
U-M PIs: Yongqing Li & Hasan Alam

 

PAD2 Mediates Caspase-1 Associated Lethality in Pseudomonas Aeruginosa Pneumonia Induced Sepsis
Journal of Infectious Disease
U-M PIs: Yongqing Li & Hasan Alam

 

Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock
Inflammation
U-M PIs: Yongqing Li & Hasan Alam

 

Hemoglobin and erythrocyte count are independently and positively associated with arterial stiffness in a community-based study
Journal of Human Hypertension
U-M PI: Santhi Ganesh
PKUHSC PI: Yan Zhang

 

Clopidogrel Resistance in a Murine Model of Diet-Induced Obesity Is Mediated by the Interleukin-1 Receptor and Overcome With DT-678
Arteriosclerosis, Thrombosis, and Vascular Biology
U-M PIs: Daniel Eitzman, Haoming Zhang & Eugene Chen
PKUHSC PI: Jianping Li

 

2019

Podocytes and autophagy: A potential therapeutic target in lupus nephritis
Autophagy
PKUHSC PI: Hong Zhang

 

Autophagy and immunological aberrations in systemic lupus erythematosus
European Journal of Immunology
PKUHSC PI: Hong Zhang

 

Disruption of Histidine and Energy Homeostasis in Chronic Obstructive Pulmonary Disease
International Journal of Chronic Obstructive Pulmonary Disease
U-M PI: Theodore Standiford
PKUHSC PI: Bei He

 

Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study
Scientific Reports
U-M PI: Theodore Standiford
PKUHSC PI: Bei He

 

Training Pathways to Working as a General Practitioner in China
Family Medicine
U-M PI: Michael Fetters

 

Survey of Nonalcoholic Fatty Liver Disease Knowledge, Nutrition, and Physical Activity Patterns Among the General Public in Beijing, China
Digestive Diseases and Sciences
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

 

Awareness and Knowledge of Nonalcoholic Fatty Liver Disease Among Office Employees in Beijing, China
Digestive Diseases and Sciences
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

 

Accumulation, Liver Fibrosis, and Metabolic Abnormalities in Chinese Patients With Moderate/Severe Versus Mild Hepatic Steatosis
Hepatology Communication
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

 

Sorafenib Encapsulated in Nanocarrier Functionalized With glypican-3 Specific Peptide for Targeted Therapy of Hepatocellular Carcinoma
Colloids and Surfaces B: Biointerfaces
U-M PI: Thomas Wang
PKUHSC PI: Jiye Zhu

 

Peptidylarginine Deiminase 2 Knockout Improves Survival in Hemorrhagic Shock
Shock
U-M PIs: Hasan Alam, Yongqing Li & Thomas Wang
PKUHSC PIs: Tianbing Wang & Baoguo Jiang

 

OHMI: the ontology of host-microbiome interactions
Journal of Biomedical Semantics
U-M PI: Oliver He
PKUHSC PI: Jianmin Wu

 

Increased mitochondrial NADPH oxidase 4 (NOX4) expression in aging is a causative factor in aortic stiffening
Redox Biology
U-M PI: Marschall Runge
PKUHSC PI: You Yi Zhang

 

Clinical Implications of Identifying Pathogenic Variants in Individuals With Thoracic Aortic Dissection
Circulation: Genomic and Precision Medicine
U-M PI: Cristen Willer

 

HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction.
EBioMedicine
U-M PIs: Zhong Wang, Hasan Alam, Yongqing Li & Eugene Chen

 

Effects of medication-assisted treatment on mortality among opioids users: a systematic review and meta-analysis
Molecular Psychiatry
U-M PIs: Fred Blow & Mark Ilgen
PKUHSC PI: Lin Lu

 

The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies
Translational Psychiatry
PKUHSC PI: Lin Lu

 

2018

Profile of psychiatric symptoms in methamphetamine users in China: Greater risk of psychiatric symptoms with a longer duration of use
Psychiatry Research
PKUHSC PI: Lin Lu

 

Epidemiological characteristics and risk factors of methamphetamine-associated psychotic symptoms
Frontiers in Psychiatry
PKUHSC PI: Lin Lu

 

Poly-drug use of prescription medicine among people with opioid use disorder in China: A systematic review and meta-analysis
Substance Use and Misuse
PKUHSC PI: Lin Lu

 

Serum uromodulin and progression of kidney disease in patients with chronic kidney disease
Journal of Translational Medicine
PKUHSC PI: Minghui Zhao

 

Increased autophagy is cytoprotective against podocyte injury induced by antibody and interferon-alpha in lupus nephritis
Annals of the Rheumatic Diseases
PKUHSC PI: Hong Zhang

 

Exploring the Role of Autophagy-Related Gene 5 (ATG5) Yields Important Insights Into Autophagy in Autoimmune/Autoinflammatory Diseases
Frontiers in Immunology
PKUHSC PI: Hong Zhang

 

Mortality risk of chronic kidney disease: A comparison between the adult populations in urban China and the United States
PLoS One
U-M PI: Jennifer Bragg-Gresham

 

Prevalence and Risk Factors for CKD: A Comparison Between the Adult Populations in China and the United States.
Kidney International Reports
U-M PI: Jennifer Bragg-Gresham
PKUHSC PI: Ming-hui Zhao

 

Variation in doses and duration of particulate matter exposure in bronchial epithelial cells results in upregulation of different genes associated with airway disorders
Toxicology In Vitro
U-M PI: Steven Huang
PKUHSC PI: Yahong Chen

 

Multiregional sequencing reveal genomic alterations and clonal dynamics in primary malignant melanoma of the esophagus
Cancer Research
U-M PI: Jun Li
PKUHSC PI: Yang Ke

 

Inhibition of Peptidylarginine Deiminase Alleviates LPS-induced Pulmonary Dysfunction and Improves Survival in a Mouse Model of Lethal Endotoxemia
European Journal of Pharmacology
U-M PIs: Hasan Alam & Yongqing Li

 

Relationship between the duration of methamphetamine use and psychotic symptoms: A two-year prospective cohort study
Drug and Alcohol Dependence
U-M PI: Fred Blow

 

Myeloperoxidase mediated HDL oxidation and HDL proteome changes do not contribute to dysfunctional HDL in Chinese subjects with coronary artery disease
PLoS One
U-M PI: Eugene Chen
PKUHSC PI: Guisong Wang

 

Effect of Ambient Fine Particulate Matter Air Pollution and Colder Outdoor Temperatures on High-Density Lipoprotein Function
American Journal of Cardiology
U-M PI: Robert Brook

 

Short-Term Blood Pressure Responses to Ambient Fine Particulate Matter Exposures at the Extremes of Global Air Pollution Concentrations
American Journal of Hypertension
U-M PI: Robert Brook
PKUHSC PI: Jianping Li

 

Structural basis for the antiarrhythmic blockade of a potassium channel with a small molecule
FASEB Journal
U-M PI: Jose Jalife

 

Minocycline effects on intracerebral hemorrhage-induced iron overload in aged rats: brain iron quantification with MRI
Stroke
U-M PI: Guohua Xi

 

Early Hemolysis Within Human Intracerebral Hematomas: an MRI Study
Translational Stroke Research
U-M PI: Guohua Xi

 

Urinary Epidermal Growth Factor Predicts Renal Prognosis in Antineutrophil Cytoplasmic Antibody-associated Vasculitis
Annals of Rheumatic Diseases
U-M PI: Wenjun Ju
PKUHSC PI: Ming-hui Zhao

 

2017

Pattern and related factors of cognitive impairment among chronic methamphetamine users
American Journal of Addiction
PKUHSC PI: Lin Lu

 

Chinese herbal medicine for the treatment of drug addiction
International Review of Neurobiology
PKUHSC PI: Lin Lu

 

Accelerated podocyte detachment and progressive podocyte loss from glomeruli with age in Alport Syndrome
Kidney International
U-M PI: Roger Wiggins
PKUHSC PI: Jie Ding

 

Collaboration platforms in China for translational and clinical research: the partnership between Peking University Health Science Center and the University of Michigan Medical School
Academic Medicine
U-M PI: Joseph Kolars
PKUHSC PI: Weigang Fang

 

Education Improves Patient Knowledge and Acceptance on Antiviral Therapy of Hepatitis C in Rural China
Chinese Medical Journal
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

 

Risk Assessment of Hepatocellular Carcinoma in Patients with Hepatitis C in China and the USA
Digestive Disease and Sciences
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

 

Temporal changes in the modes of hepatitis C virus transmission in the USA and Northern China
Digestive Disease and Sciences
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

 

Mutation landscape and intratumor heterogeneity of two MANECs of the esophagus revealed by multi-region sequencing
Oncotarget
U-M PI: Jun Li
PKUHSC PI: Yang Ke

 

The higher prevalence of truncal obesity and diabetes in American than Chinese patients with chronic hepatitis C might contribute to more rapid progression to advanced liver disease
Alimentary Pharmacology & Therapeutics
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

 

CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock
Scientific Reports
U-M PI: Hasan Alam
PKUHSC PI: Baoguo Jiang

 

Personal-level exposure to environmental temperature is a superior predictor of edothelialdpendent vasodilatation than outdoor-ambient level
Journal of the American Society of Hypertension
U-M PI: Robert Brook
PKUHSC PI: Jianping Li

 

Transplantation of multipotent Isl1+ cardiac progenitor cells preserves infarcted heart function in mice
American Journal of Translational Research
U-M PI: Zhong Wang
PKUHSC PI: Hongkuei Deng

 

Air Pollution and Cardiometabolic Disease: An Update and Call for Clinical Trials
American Journal of Hypertension
U-M PI: Robert Brook
PKUHSC PI: Jianping Li

 

Transplantation of Isl1+ Cardiac Progenitor Cells in Small Intestinal Submucosa Improves Infarcted Heart Function
Stem Cell Research Therapy
U-M PI: Zhong Wang

 

CD163 expression in neurons after experimental intracerebral hemorrhage
Stroke
U-M PI: Guohua Xi
PKUHSC PI: Yining Huang

 

Eplerenone Reduces Atrial, Fibrillation Burden Without Preventing Atrial Electrical Remodeling
Journal of the American College of Cardiology
U-M PI: Jose Jalife

 

“Stressed” About Air Pollution: Time for Personal Action
Circulation
U-M PI: Robert Brook
PKUHSC PI: Jianping Li

 

Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants contributing to lipid levels and coronary artery disease
Nature Genetics
U-M PI: Christen Willer
PKUHSC PI: Ming-Hsu

 

Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency
Cell
U-M PI: Zhong Wang
PKUHSC PI: Hongkuei Deng

 

2016

In vivo photoacoustic tomography of EGFR overexpressed in hepatocellular carcinoma mouse xenograft
Photoacoustics
U-M PI: Thomas Wang
PKUHSC PI: Jiye Zhu

 

A Comparative Study of Liver Disease Care in the USA and Urban and Rural China
Digestive Disease and Sciences
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

 

In vivo fluorescence imaging of hepatocellular carcinoma xenograft using near-infrared labeled epidermal growth factor receptor (EGFR)
Biomedical Optic Express
U-M PI: Thomas Wang
PKUHSC PI: Jiye Zhu

 

Survey of hepatitis B knowledge and stigma among chronically infected patients and uninfected persons in Beijing, China.
Liver International
U-M PI: Anna Lok
PKUHSC PI: Lai Wei

 

Protective effect of Cl-amidine against CLP-induced lethal septic shock in mice
Scientific Reports
U-M PI: Hasan Alam
PKUHSC PI: Baoguo Jiang

 

Quantitative analysis of MR imaging to assess treatment response for patients with multiple myeloma by using dynamic intensity entropy transformation: a preliminary study
Radiology
U-M PI: Qian Dong
PKUHSC PI: Jin Lu

 

Galectin-3 Regulates Atrial Fibrillation Remodeling and Predicts Catheter Ablation Outcomes. JACC: Basic to Translational Science
JACC: Basic to Translational Science
U-M PI: Jose Jalife

 

Improving cardiac reprogramming for heart regeneration
Current Opinion in Organ Transplantation
U-M PI: Zhong Wang
PKUHSC PI: Hongkuei Deng

 

Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts
Cell Discovery
U-M PI: Zhong Wang
PKUHSC PI: Hongkuei Deng

 

Atrial Fibrillation Susceptibility in Obesity: An Excess Adiposity and Fibrosis Complicity?
Circulation Research
U-M PI: Jose Jalife

 

Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits
Nature Genetics
U-M PI: Santhi Ganesh
PKUHSC PI: Yan Zhang 2016

 

2015

NEPTUNE and PKU-IgAN Consortium (2015) Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker
Science Translational Medicine
U-M PI: Mattias Kretzler
PKUHSC PI: Minghuei Zhao